Americans Shane Kimbrough and Megan McArthur, Frenchman Thomas Pesquet and Japanese flier Akihiko Hoshide rode to orbit in a Dragon capsule launched atop a Falcon 9 rocket.
They should arrive at the space station on Saturday to begin a six-month tour of duty. Lift-off occurred pre-dawn at 05:49 EDT (09:49 GMT; 10:49 BST).
The new crew's arrival at the ISS will bring the onboard complement at the high-flying outpost to 11 individuals, albeit briefly.
The arriving team are performing what's called a direct handover to the previous Dragon crew (Mike Hopkins, Victor Glover, Soichi Noguchi and Shannon Walker), who are expected to come home next week.
Read more at : https://www.bbc.com/news/science-environment-56858789